Tumor Treating Fields (TTFields) competence beyond combating cancer: the BBB story

Time: 9:45 am
day: Day One


• TTFields disrupt the blood-brain barrier (BBB) in vitro and in vivo
• Recovery of the BBB after TTFields treatment ensues within 48-96h
• TTFields application promotes claudin 5 phosphorylation in a ROCK-dependent manner
• The established in vitro model could be used for pre-assessment of drug delivery across the BBB in combination with TTFields therapy to treat GBM