Bo Feng

Bo Feng

Company: Vertex Pharmaceuticals

Job title: Senior Director DMPK


Using in vitro & in vivo Approaches to Quantitatively Predict CNS Penetration of Efflux Transporter Substrates 11:00 am

• Exploring available in vitro transporter and permeability assays • Contemplating in vivo neuro-PK in different species • Developing the correlation between in vitro and in vivo to predict human brain penetrationRead more

day: Day Two

Panel: Quantifying Barrier Penetration & Understanding Efficacy 12:15 pm

• How can we enumerate drug concentration through the barriers in vivo? • What approaches can be made to demonstrate efficacy? • What are the crucial issues in validating estimations?Read more

day: Day One

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